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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Dev Biol. 2008 Jun 20;321(1):197–204. doi: 10.1016/j.ydbio.2008.06.017

Fig. 6.

Fig. 6

Ablation of Pten and Foxo3 in tamoxifen-treated adult Vasa-CreERT2 females results in global primordial follicle activation. (A) Pten (B) Foxo3. Bar = 1 mm. For both experiments, females were treated with tamoxifen and ovaries harvested 3 weeks later; controls were untreated siblings of the same genotype. Ablation of Pten and Foxo3 resulted in identical ovarian hypertrophy phenotypes; histological examination (H&E) confirmed that ovarian hypertrophy was due to global primordial follicle activation. Size bar = 50 μ. All corresponding panels in A and B are at the same magnification.