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. Author manuscript; available in PMC: 2009 Feb 21.
Published in final edited form as: J Theor Biol. 2007 Oct 18;250(4):732–751. doi: 10.1016/j.jtbi.2007.10.015

Table A.3.

Sensitivity of CD4+ T cell output to full model parameters by PRC analysis

Parameter 1 day 2 days 3 days 4 days 5 days 6 days 7 days
CD4+ T cells (primed:naïve)
  Recruitment ↓
  doubling time ↓↓↓ ↓↓↓ ↓↓ ↓↓ ↓↓ ↓↓
  number of divisions ↑↑ ↑↑ ↑↑↑ ↑↑ ↑↑ ↑↑
CD8+ T cells (primed:naïve)
  recruitment
  doubling time ↑↑
Primed CD4 binds DC ↑↑↑ ↑↑
Short-term persistence ↑↑↑ ↑↑↑ ↑↑↑ ↑↑
CD4+ T cell chemotaxis
  strength
  duration ↓↓ ↓↓
  recovery
CD8+ T cell chemotaxis
  strength
  duration ↓↓
  recovery

Cognate: non-cognate ratio = 1:300

ns = p > 0.000358 (threshold based on Bonferroni correction)

↓ or ↑ = p < 0.000358, with negative or positive association

↓↓ or ↑↑ = p < 10−5, with negative or positive association

↓↓↓ or ↑↑↑ = p < 10−6, with negative or positive association

↓↓↓↓ or ↑↑↑↑ = p < 10−9, with negative or positive association