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. Author manuscript; available in PMC: 2009 Feb 21.
Published in final edited form as: J Theor Biol. 2007 Oct 18;250(4):732–751. doi: 10.1016/j.jtbi.2007.10.015

Table A.4.

Sensitivity of CD8+ T cell output to full model parameters by PRC analysis

Parameter 1 day 2 days 3 days 4 days 5 days 6 days 7 days
CD4+ T cells
  recruitment ↓ ↓↓ ↓↓↓ ↓↓↓
  doubling time ↓↓ ↓↓ ↓↓↓ ↓↓↓ ↓↓↓
  number of divisions ↓↓ ↓↓ ↓ ↓ ↓
  Antigen-bearing DC activation ↑ ↑↑↑ ↑↑ ↑↑
CD8+ T cells
  cognate binding to LDC ↑ ↑ ↑
  LDC activation ↑ ↑ ↑
Primed CD4 binds DC ↑
Primed T cell matures DC ↑ ↑ ↑
Short-term persistence
CD4+ T cell chemotaxis
  strength
  duration ↓ ↓ ↓ ↓
  recovery ↑
CD8+ T cell chemotaxis
  strength
  duration
  recovery

Cognate: non-cognate ratio = 1:300

ns = p > 0.000358 (threshold based on Bonferroni correction)

↓ or ↑ = p < 0.000358, with negative or positive association

↓↓ or ↑↑ = p < 10−5, with negative or positive association

↓↓↓ or ↑↑↑ = p < 10−6, with negative or positive association

↓↓↓↓ or ↑↑↑↑ = p < 10−9, with negative or positive association