Fig. 5.

free energy landscapes of the hairpin of Fig. 1c (n = 13) as obtained from the KIS model (a–d). (Un)folding pathways characteristic of the above landscapes are represented by 1D profiles (e). The behavior at T = 360 K is magnified in the lower right panel to illustrate the onset of the kinetic intermediate state with a free energy of about −2 kJ· mol⁻¹ and a barrier for unzipping of about 5 kJ·mol⁻¹ (f).