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Structurally conserved loop segments (QSDL) of the class of long QSDL (red) and short QSDL (blue). The representative QSDL for each family is shown. (Red) Horse liver ADH (PDB entry: 1HEU); (blue) Aeropyrum pernix ADH (PDB entry: 1H2B). QSDL-start and QSDL-end are labeled. The conserved salt bridge network in long QSDL MDRs (side chains of Asp125, Arg129, Glu35) are shown as sticks and colored by atom type.
