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Schematic representation of the proposed model for the interaction between the FGFR and NCAM. (A) The NCAM is not involved in the trans-homophilic binding, and there is no substantial binding between the FGFR and NCAM. (B) The NCAM is involved in trans-homophilic binding and the FGFR binds to two neighboring NCAM molecules belonging to the different cis-dimers. (C) The FGFR is bound to two NCAM molecules belonging to the same cis-dimer.
