Figure 9.

The TOR toxic domain is conserved and shares identity with regions of the PIK family members, ATR, Rad3, mei-41, and ATM. The TOR1 (amino acids 1376–1614), TOR2 (amino acids 1383–1620), and mTOR/RAFT/FRAP-toxic domains (amino acids 1427–1663) were used for BLAST searches of the NCBI database, revealing sequence similarity with ATR (amino acids 1688–1923) and Rad3 (amino acids 725–950), mei-41 (amino acids 1396–1623), and ATM (amino acids 1985–2148). The alignment shown here was generated using the ClustalW program of MacVector software. Residues that are conserved in four of the seven proteins are boxed, shaded, and in bold. Similar residues are boxed.