Table 5.
Relationship of antisaccade performance to cognitive test scores
| Domain | Test | FTLD |
AD |
||||
|---|---|---|---|---|---|---|---|
| Mean | Correct | Total | Mean | Correct | Total | ||
| General | MMSE | 23.2 (1.1) | −0.072 | 0.135 | 18.9 (1.5) | 0.631 | 0.586 |
| CDR | 0.73 (0.08) | −0.136 | −0.270 | 0.77 (0.06) | −0.072 | −0.096 | |
| CDR SOB | 4.2 (0.44) | −0.003 | −0.192 | 5.0 (0.41) | 0.170 | 0.170 | |
| Memory | List recall (30″) | 3.5 (0.54) | −0.241 | −0.210 | 2.2 (0.61) | 0.760 | 0.805 |
| List recall (10′) | 2.8 (0.52) | −0.347 | −0.050 | 1.5 (0.70) | 0.602 | 0.575 | |
| Figure recall (10′) | 8.3 (0.85) | 0.219 | 0.288 | 5.0 (1.7) | 0.422 | 0.514 | |
| Spatial | Figure copy | 15.5 (0.57) | −0.023 | 0.281 | 11.5 (1.6) | 0.517 | 0.598 |
| Designs/min | 5.9 (0.75) | 0.413 | 0.570 | 4.4 (1.5) | 0.346 | 0.247 | |
| Language | Animals/min | 8.2 (1.1) | −0.335 | −0.141 | 10.1 (2.0) | 0.720 | 0.687 |
| D words/min | 7.4 (1.5) | 0.081 | −0.126 | 8.5 (1.6) | 0.687 | 0.621 | |
| Mod. BNT | 7.6 (1.3) | −0.361 | −0.050 | 7.7 (2.0) | 0.467 | 0.536 | |
| Executive | Calculations | 3.9 (0.26) | 0.505 | 0.405 | 2.9 (0.45) | 0.555 | 0.797 |
| Digits backward | 3.9 (0.30) | 0.704 | 0.293 | 2.6 (0.52) | 0.502 | 0.517 | |
| Trails (s) | 64.2 (8.0) | −0.277 | −0.523 | 95.7 (11) | −0.813 | −0.826 | |
| Trails (# correct) | 11.3 (0.9) | 0.526 | 0.543 | 6.6 (2.0) | 0.906 | 0.887 | |
| Trails (# errors) | 1.4 (0.40) | −0.677 | −0.605 | 0.9 (0.50) | 0.383 | −0.311 | |
| Stroop (# correct) | 32.6 (3.8) | 0.038 | 0.302 | 20.9 (5.6) | 0.929 | 0.619 | |
| Stroop (errors) | 1.0 (0.43) | −0.173 | −0.601 | 5.9(3.5) | −0.916 | −0.868 | |
For both FTLD and AD, the column labeled ′Mean′ shows mean (± SEM) values for each neuropsychological measure. The columns labeled ′Correct′ and ′Total′ give the Spearman correlation coefficients for each measure as related to the percentage of correct antisaccade responses (correct) or the percentage of correct responses plus corrected error responses (total). Bold values for correlations indicate p < 0.05, two-tailed, multiple comparisons corrected with false discovery rate procedure. CDR SOB, CDR sum of boxes; Mod. BNT, modified Boston Naming Test.