Table 6.

Regional brain atrophy correlated with saccade performance

Functional region	Anatomic description	BA	x	y	z	Z-score	p value
Covariate: percentage correct antisaccade responses
Right FEF	middle frontal gyrus/ precentral sulcus	6	61	4	42	4.76	0.007
Covariate: antisaccade latency
Right SEF > pSMA	Medial superior frontal gyrus	6	0	19	58	5.50	<0.001
Left pSMA > SEF	Inferior/medial superior frontal gyrus	6	−1	26	48	5.47	<0.001
Covariate: visually guided saccade latency (overlap condition)
Unknown	Rostral left superior frontal gyrus	6	−15	46	36	4.59	0.015

Columns labeled x, y, and z indicate MNI (Evans et al., 1993) coordinates. Z-score and p value indicate the statistical significance of the best voxel identified from each VBM correlation. p value is corrected for multiple comparisons (family-wise error). Many oculomotor variables were not correlated with brain atrophy in any region: correct antisaccade responses plus corrected errors, antisaccade gain, latency of correct antisaccade responses, latency of antisaccade errors, proportion of corrected antisaccade errors, visually-guided saccade latency (gap task), visually-guided saccade velocity, visually-guided saccade gain, pursuit parameters. BA, Brodmann's area; pSMA, pre-SMA.