Table 6.
Drug dosage and plasma concentration in the multitarget therapy group
| Parameter | Baseline Value (n = 20) | Week 1 (n = 20) | 1 Mo (n = 20) | 3 Mo (n = 19) | 6 Mo (n = 18) | 9 Mo (n = 8) |
|---|---|---|---|---|---|---|
| MMF (g/d) | 0.91 ± 0.12 | 0.91 ± 0.12 | 0.93 ± 0.22 | 0.89 ± 0.20 | 0.88 ± 0.21 | 0.84 ± 0.18 |
| MPA AUC0–12 h (mg·h/L) | – | 28.03 ± 7.13 | 31.34 ± 6.43 | 31.17 ± 7.53 | 31.44 ± 9.44 | 29.11 ± 7.80 |
| Tacrolimus (mg/d) | 3.65 ± 0.48 | 3.65 ± 0.48 | 3.70 ± 0.86 | 3.57 ± 0.90 | 3.75 ± 1.03 | 3.75 ± 1.28 |
| Ctrough (ng/ml)a | – | 5.90 ± 2.87 | 5.90 ± 1.51 | 5.86 ± 1.50 | 5.61 ± 1.29 | 6.19 ± 1.42 |
| Prednisone (mg/d) | 35.7 ± 8.6 | 35.7 ± 8.6 | 35.7 ± 8.6 | 19.0 ± 6.7 | 10.2 ± 1.1 | 10.0 ± 0.0 |
a
The blood trough concentrations (12 h postdose) of tacrolimus.