Table 2.

Multivariable adjusted relative hazard of CKD progression during a median follow-up of 14 yr with TCF7L2 variants in 10786 white and 3599 black ARIC participants^a

Marker	White					Black
	HRb	95% CI	P	Events	n	HRb	95% CI	P	Events	n
rs12255372
overall	1.13	1.00 to 1.28	0.040	629	10,452	1.07	0.91 to 1.25	0.421	350	3522
no diabetes	1.12	0.98 to 1.29	0.099	474	9553	1.05	0.86 to 1.28	0.649	219	2963
diabetes	1.18	0.93 to 1.49	0.177	155	899	1.10	0.85 to 1.44	0.459	131	559
rs7903146
overall	1.17	1.04 to 1.32	0.008	635	10,476	1.20	1.03 to 1.41	0.023	349	3537
no diabetes	1.18	1.03 to 1.35	0.019	477	9566	1.10	0.89 to 1.35	0.375	219	2980
diabetes	1.19	0.94 to 1.51	0.150	158	910	1.32	1.03 to 1.71	0.031	130	557
rs7901695
overall	1.19	1.06 to 1.34	0.002	636	10,527	1.27	1.09 to 1.48	0.002	350	3546
no diabetes	1.20	1.05 to 1.37	0.009	477	9613	1.22	1.01 to 1.48	0.036	220	2987
diabetes	1.21	0.96 to 1.52	0.111	159	914	1.36	1.05 to 1.76	0.018	130	559
rs11196205
overall	1.15	1.03 to 1.29	0.011	635	10,524	1.06	0.88 to 1.28	0.514	351	3559
no diabetes	1.12	0.99 to 1.28	0.070	477	9608	0.97	0.77 to 1.21	0.779	220	2998
diabetes	1.26	1.00 to 1.58	0.045	158	916	1.21	0.88 to 1.67	0.238	131	561

^aResults obtained from a model adjusting for baseline gender, BMI, SBP, antihypertensive medication intake, fasting glucose, study center, smoking, and diabetes in the overall analyses.

^bHR are for each copy of the known diabetes-susceptibility allele (rs12255372 [T]; rs7903146 [T]; rs7901695 [C]; rs11196205 [C]).