Table 3.

Sensitivity analyses of the association of TCF7L2 variants and CKD progression in white and black ARIC participants to investigate the contribution of incident diabetes and impaired fasting glucose^a

SNP	White ARIC Participants					Black ARIC Participants
	HR	95% CI	P	Events	n	HR	95% CI	P	Events	n
rs7903146
model 1b	1.17	1.02 to 1.34	0.024	477	9566	1.09	0.89 to 1.34	0.407	219	2980
model 2b	1.12	0.96 to 1.30	0.138	399	9566	1.02	0.81 to 1.29	0.871	174	2980
model 3b	1.07	0.87 to 1.33	0.505	211	5570	1.04	0.77 to 1.39	0.798	108	1676
rs7901695
model 1b	1.19	1.04 to 1.36	0.010	477	9613	1.22	1.01 to 1.47	0.042	220	2987
model 2b	1.16	1.00 to 1.34	0.047	400	9613	1.20	0.97 to 1.48	0.093	176	2987
model 3b	1.10	0.90 to 1.35	0.359	210	5624	1.26	0.96 to 1.65	0.090	108	1679

^aData presented for rs7903146 and rs7901695 only because these were the variants showing a significant association in both races.

^bModel 1 evaluates individuals without baseline diabetes and incorporates diabetes and fasting glucose as time-dependent variables into the multivariable adjusted Cox model. Model 2 treats CKD progression and incident diabetes as competing events, removing individuals from the analysis at the date of incident diabetes when this date was before or the same as the date of CKD progression and accounts for time-dependent fasting glucose. Model 3 additionally excludes individuals with baseline fasting glucose ≥100 mg/dl.