Table 4.

Results from linear regression of ln(eGFR) and ln(cystatin C) and logistic regression of eGFR <60 ml/min per 1.73 m² at the FHS cycle 7 examination on rs12255372 and rs7903146 in FHS participants^a

SNP	Coefficient	SE	P	n
Linear regression of ln(eGFR)
rs12255372
overall	−0.015	0.008	0.047	2306
no diabetes	−0.009	0.008	0.261	2041
rs7903146
overall	−0.018	0.007	0.010	2323
no diabetes	−0.013	0.007	0.066	2056
Linear regression of ln(cystatin C)
rs12255372
overall	0.016	0.006	0.006	2263
no diabetes	0.013	0.006	0.015	2004
HbA1c <6.0%	0.015	0.005	0.006	1596
FPG <100 mg/dl	0.010	0.007	0.159	1231
rs7903146
overall	0.016	0.006	0.004	2279
no diabetes	0.014	0.005	0.010	2018
HbA1c <6.0%	0.014	0.005	0.001	1602
FPG <100 mg/dl	0.009	0.007	0.177	1237
Logistic regression of eGFR <60 ml/min per 1.73 m2	OR	95% CI	P	n
rs12255372
overall	1.13	0.91 to 1.40	0.253	2306
no diabetes	1.09	0.86 to 1.39	0.472	2041
rs7903146
overall	1.18	0.98 to 1.41	0.079	2323
no diabetes	1.18	0.96 to 1.46	0.115	2056

^aModel adjusted for age, gender, SBP, antihypertensive medication intake, BMI, fasting glucose, smoking, and diabetes in the overall model. OR, odds ratio; HbA_1c, hemoglobin A1c; FPG, fasting plasma glucose.