Table 1.

Physiologic measurements before and during ouabain infusion^a

Parameter	MAP (mmHg)	HR (bpm)	Hct (%)	PNa (mEq/L)	PK (mEq/L)	GFR (μl/min per g)
α1R/Rα2R/R (n = 7)
basal	85 ± 3	489 ± 15	48 ± 2	155 ± 2	4.6 ± 0.4	1045 ± 125
saline 1	85 ± 3	559 ± 16	48 ± 2	160 ± 1	4.6 ± 0.5	1156 ± 124
saline 2	81 ± 4	563 ± 19	48 ± 2	156 ± 1	4.7 ± 0.4	1129 ± 156
α1S/Sα2R/R (n = 9)
basal	95 ± 5	458 ± 12	49 ± 1	163 ± 1	5.0 ± 0.2	956 ± 82
saline 1	110 ± 5b,c	496 ± 14	51 ± 1	161 ± 1	6.3 ± 0.3b,c	1033 ± 85
saline 2	107 ± 4b,c	476 ± 10	51 ± 1	160 ± 3	7.2 ± 0.4b,c	528 ± 136b,c
α1R/Rα2S/S (n = 8)
basal	93 ± 4	438 ± 25	49 ± 1	158 ± 2	4.5 ± 0.1	1224 ± 68
saline 1	99 ± 4	500 ± 37	52 ± 1	160 ± 2	4.9 ± 0.2	1165 ± 81
saline 2	94 ± 5	506 ± 47	52 ± 1	157 ± 2	6.7 ± 0.4b,c	1164 ± 112
Two-way ANOVA
group	0.005	0.140	0.180	0.160	0.003	0.037
treatment	0.005	<0.001	0.024	0.022	<0.001	0.018
group × treatment	0.038	0.200	0.340	0.110	<0.001	0.003

^aHct, hematocrit; HR, heart rate; P_Na and P_K, plasma concentration of Na⁺ and K⁺.

Post-hoc analyses:

^bP < 0.05 versus basal level in same group;

^cP < 0.05 versus corresponding level in α1^R/Rα2^R/R.