Table 2.
Parameter | MAP (mmHg) | HR (bpm) | Hct (%) | PNa (mEq/L) | PK (mEq/L) | GFR (μl/min per g) |
---|---|---|---|---|---|---|
α1R/Rα2R/R (n = 7) | ||||||
basal | 82 ± 1 | 421 ± 28 | 51 ± 1 | 159 ± 1 | 4.3 ± 0.3 | 1259 ± 162 |
saline 1 | 83 ± 2 | 452 ± 24 | 48 ± 1 | 158 ± 1 | 4.6 ± 0.3 | 1267 ± 183 |
saline 2 | 86 ± 2 | 459 ± 20 | 47 ± 1 | 158 ± 2 | 4.8 ± 0.2 | 1315 ± 251 |
α1S/Sα2R/R (n = 8) | ||||||
basal | 85 ± 2 | 385 ± 11 | 49 ± 0 | 156 ± 1 | 4.4 ± 0.2 | 1115 ± 79 |
saline 1 | 88 ± 2 | 438 ± 13 | 48 ± 1 | 157 ± 1 | 4.7 ± 0.3 | 1179 ± 64 |
saline 2 | 91 ± 3 | 446 ± 17 | 47 ± 1 | 155 ± 1 | 5.0 ± 0.3 | 1334 ± 83 |
α1R/Rα2S/S (n = 11) | ||||||
basal | 81 ± 2 | 409 ± 11 | 51 ± 1 | 157 ± 1 | 4.8 ± 0.2 | 1337 ± 46 |
saline 1 | 79 ± 2 | 441 ± 15 | 47 ± 1 | 157 ± 1 | 4.8 ± 0.2 | 1347 ± 117 |
saline 2 | 81 ± 2 | 449 ± 14 | 45 ± 1 | 157 ± 1 | 5.0 ± 0.2 | 1357 ± 135 |
Two-way ANOVA | ||||||
group | 0.011 | 0.670 | 0.510 | 0.440 | 0.730 | 0.700 |
treatment | 0.070 | <0.001 | <0.001 | 0.270 | 0.003 | 0.012 |
group × treatment | 0.433 | 0.370 | 0.180 | 0.470 | 0.590 | 0.190 |