Figure 3.

The aberrant del(7b-14a) RET transcript lacks key functional domains. CLD1 through 4, CRD, transmembrane segment (TM), juxtamembrane segment (JM), and two cytoplasmic tyrosine kinase domains (TK1 and TK2) are displayed adjacent to the corresponding exon structure of the wild-type RET transcript (WT). To the left is the aberrant del(7b-14a) transcript associated with 1476(A) alleles; deletion of extracellular domains for ligand (GDNF) and co-receptor (GFRα1), transmembrane segments, and a large portion of TK1 is predicted, rendering the transcript nonfunctional.