Table 3.
Pharmacokinetic profile
| Study medication | Water Volume | Dose pre-meal | AUC0–4 pg/ml × hrs | Cmax pg/ml | Tmax minutes |
| SMC021 | 50 ml | 10 min | 52.2 (46.0–59.4) | 103 (89–118) | 15 (10–23) |
| SMC021 | 50 ml | 30 min | 68.9 (60.2–78.9) | 125 (110–144) | 15 (15–30) |
| SMC021 | 50 ml | 60 min | 74.4 (64.0–86.5) | 145 (125–168) | 15 (15–30) |
| SMC021 | 200 ml | 10 min | 27.4 (25.2–29.7) | 52 (45–59) | 15 (10–15) |
| SMC021 | 200 ml | 30 min | 32.9 (29.1–37.3) | 56 (48–67) | 15 (15–30) |
| SMC021 | 200 ml | 60 min | 33.6 (29.5–38.1) | 49 (42–58) | 15 (12.5–30) |
| Miacalcic | N/A | 60 min | 16.4 (13.8–19.4) | 11.4 (8.3–15.5) | 15 (10–15) |
AUC0–4 and Cmax is given as geometric mean (mean ± 1 sem), and Tmax as median (25–75 percentile)