Table 1.
Demographic and clinical profile by group and age of diagnosis of type 2 diabetes
| Group A (duration of diabetes 20–30 years, n = 624) |
Group B (duration of diabetes 10–12 years, n = 852) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Age of diagnosis (years) |
P | Age of diagnosis (years) |
P | |||||
| <45 | 45–55 | >55 | <45 | 45–55 | >55 | |||
| n | 322 | 232 | 70 | 236 | 293 | 323 | ||
| Age at last examination (years) | 63.0 (53.8–66.4) | 72.8 (70.2–75.4) | 80.8 (78.8–83.0) | <0.0001 | 50.2 (46.3–52.9) | 61.9 (59.4–64.0) | 71.8 (69.3–75.4) | <0.0001 |
| Duration (years) | 24.2 (21.7–27.2) | 22.8 (20.9–25.2) | 22.1 (20.7–23.7) | <0.0001 | 10.9 (10.5–11.5) | 11.1 (10.5–11.6) | 10.9 (10.5–11.4) | 0.3 |
| Male (%) | 55.0 | 53.9 | 57.1 | 0.9 | 59.8 | 58.0 | 51.1 | 0.08 |
| Retinopathy (%) | 61.8 | 50.0 | 40.0 | 0.0006 | 39.8 | 42.3 | 24.8 | <0.0001 |
| OR (95% CI) | 2.4 (1.4–4.1) | 1.5 (0.9–2.6) | 1 | 0.0001 (Ptrend) | 2.0 (1.4–2.9) | 2.2 (1.6–3.1) | 1 | <0.0001 (Ptrend) |
| Vision-threatening retinopathy (%) | 26.4 | 20.3 | 12.2 | 0.03 | 11.0 | 10.2 | 5.9 | 0.06 |
| OR (95% CI) | 2.4 (1.2–5.1) | 1.7 (0.8–3.7) | 1 | 0.009 (Ptrend) | 2.0 (1.1–3.7) | 1.8 (1.0–3.3) | 1 | 0.03 (Ptrend) |
| Mean A1C (%) | 8.4 ± 1.7 | 8.0 ± 1.3 | 8.2 ± 1.6 | 0.006 | 8.7 ± 1.8 | 8.2 ± 1.6 | 7.9 ± 1.6 | <0.0001 |
| Metabolic syndrome (%) | 77.0 | 72.0 | 73.5 | 0.5 | 64.7 | 71.2 | 68.8 | 0.5 |
| Systolic blood pressure (mmHg) | 132 (120–150) | 138 (125–152) | 138 (128–152) | 0.2 | 128 (117–140) | 136 (126–149) | 138 (127–153) | <0.0001 |
| Diastolic blood pressure (mmHg) | 72 (70–80) | 70 (65–80) | 70 (68–80) | 0.051 | 80 (72–86) | 80 (70–85) | 76 (70–85) | 0.002 |
| Blood pressure Rx (%) | 74.0 | 74.6 | 59.7 | 0.051 | 51.6 | 72.2 | 78.8 | <0.001 |
| Albuminuria (mg/l) | 23.7 (10.0–86.9) | 24.2 (10.0–92.0) | 26.7 (10.0–99.0) | 0.9 | 23.3 (9.0–83.3) | 16.5 (8.2–51.1) | 33.0 (11.0–104.3) | 0.002 |
| BMI (kg/m2) | 30.0 (26.2–34.2) | 28.3 (25.5–32.1) | 27.6 (22.5–30.4) | <0.0001 | 30.1 (26.5–33.5) | 29.7 (26.6–33.4) | 29.5 (26.1–32.6) | 0.09 |
| HDL (mmol/l) | 1.2 (1.0–1.4) | 1.2 (1.0–1.6) | 1.2 (1.0–1.6) | 0.8 | 1.2 (0.9–1.4) | 1.1 (1.0–1.4) | 1.2 (1.0–1.5) | 0.01 |
| Triglycerides (mmol/l) | 1.8 (1.2–2.7) | 1.5 (1.1–2.2) | 1.7 (1.0–2.5) | 0.06 | 2.0 (1.3–2.9) | 1.7 (1.2–2.7) | 1.8 (1.3–2.6) | 0.1 |
Data are means ± SD and median (interquartile range) unless otherwise indicated. P refers to χ2 or ANOVA analysis of prevalence across the different age-of-onset subgroups; Ptrend refers to trend analysis of retinopathy prevalence across the different age-of-onset subgroups.