Table 2.

β-Coefficients for the clinical, clinical + biological, and clinical + biological + genetic equations: the DESIR study

	Clinical equation		Clinical + biological equation		Clinical + biological + genetic equation
	n = 1,860 men (140 with diabetes) and n = 1,954 women (63 with diabetes)		n = 1,860 men (140 with diabetes) and n = 1,954 women (63 with diabetes)		n = 1,655 men (128 with diabetes) and n = 1,740 women (58 with diabetes)
	β	P	β	P	β	P
Men
Intercept	−10.45		−10.53		10.91
Current smoker	0.72	0.0002	0.88	0.0001	0.94	0.0001
Waist circumference (cm)	0.081	0.0001	0.060	0.0001	0.060	0.0001
Hypertension*	0.50	0.01
Fasting glucose (mmol/l)†			10.15	0.0001	10.17	0.0001
Fasting glucose2†			24.16	0.002	22.42	0.007
GGT (IU/l)†			0.39	0.01	0.42	0.007
Number of TCF7L2 and IL6 deleterious alleles					0.14	0.2
AROC statistic	0.733		0.850		0.851
Hosmer-Lemeshow fit test		0.7		0.8		0.1
Women
Intercept	−11.81		−18.91		−20.43
Diabetes in the family	1.09	0.0001	0.80	0.01	0.75	0.02
Waist circumference (cm)	0.095	0.0001
BMI (kg/m2)†			4.38	0.0001	4.69	0.0001
Hypertension*	0.64	0.03
Fasting glucose (mmol/l)†			9.66	0.001	9.35	0.001
Fasting glucose2†			23.89	0.06	22.39	0.08
Triglycerides (mmol/l)†			0.95	0.003	0.86	0.01
Number of TCF7L2 amd IL6 deleterious alleles					0.36	0.04
AROC statistic	0.839		0.917		0.912
Hosmer-Lemeshow fit test		0.6		0.9		0.8

^*Systolic/diastolic blood pressure ≥140/90 mmHg or medication for hypertension.

^†Fasting glucose, GGT, BMI, and triglycerides were log transformed.