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. 2008 Oct;57(10):2588–2594. doi: 10.2337/db07-1410

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Copyright © 2008, American Diabetes Association

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FIG. 2. — Administering intravenous bumetanide to DKA rats normalizes ADC values without significantly altering CBF. Rats were administered bumetanide (30 mg/kg) immediately before the start of imaging as described in research design and methods. A: ADC values of DKA rat cortex and striatum were determined by diffusion-weighted imaging before and 37 min after intravenous administration of bumetanide (, −Bumet; ▪, +Bumet). All values are means ± SE, n = 6. *Significantly different from pretreatment ADC values (−Bumet). P < 0.05 for both cortex and striatum. B: CBF values of DKA rat cortex and striatum were determined by perfusion-weighted imaging before and 44 min after intravenous administration of bumetanide. All values are means ± SE, n = 6. , −Bumet; ▪, +Bumet.

Inline graphic — Administering intravenous bumetanide to DKA rats normalizes ADC values without significantly altering CBF. Rats were administered bumetanide (30 mg/kg) immediately before the start of imaging as described in research design and methods. A: ADC values of DKA rat cortex and striatum were determined by diffusion-weighted imaging before and 37 min after intravenous administration of bumetanide (, −Bumet; ▪, +Bumet). All values are means ± SE, n = 6. *Significantly different from pretreatment ADC values (−Bumet). P < 0.05 for both cortex and striatum. B: CBF values of DKA rat cortex and striatum were determined by perfusion-weighted imaging before and 44 min after intravenous administration of bumetanide. All values are means ± SE, n = 6. , −Bumet; ▪, +Bumet.