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. 2008 Oct;57(10):2595–2602. doi: 10.2337/db08-0038

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Copyright © 2008, American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — TLR4 and TLR2 gene expression and protein content. TLR4 mRNA expression (A) and protein content (B) were measured in lean, obese, and type 2 diabetic (T2DM) subjects. Data are means ± SE in 7 lean, 8 obese, and 14 type 2 diabetic subjects in A and 6 lean, 8 obese, and 10 type 2 diabetic subjects in B (protein extracts were not available for all subjects). C: Correlation between TLR4 content and HOMA-IR. D: TLR2 mRNA expression in 7 lean, 8 obese, and 14 type 2 diabetic subjects. *P < 0.05 vs. lean. E: Direct Western blotting in muscle from three lean and three type 2 diabetic subjects using an antibody against human TLR2 (eBiosciences). A band corresponding to TLR2 was detected in mononuclear cells (MNCs) isolated from two subjects.