TABLE 1.
Clinical and laboratory characteristics
| Lean | Obese | Type 2 diabetes | |
|---|---|---|---|
| n | 7 | 8 | 14 |
| Sex (M/F) | 4/3 | 3/5 | 5/9 |
| Age (years) | 45 ± 2 | 44 ± 3 | 52 ± 3 |
| BMI (kg/m2) | 25.3 ± 0.7 | 30.5 ± 0.6* | 31.8 ± 1.2* |
| Fasting glucose (mmol/l) | 5.4 ± 0.2 | 5.6 ± 0.1 | 7.8 ± 0.6*† |
| Glucose AUC during OGTT (mg/dl · 2 h) | 120 ± 11 | 121 ± 8 | 230 ± 18*† |
| Fasting insulin (pmol/l) | 19 ± 4 | 92 ± 16* | 86 ± 16* |
| HOMA-IR | 0.6 ± 0.1 | 2.0 ± 0.3* | 2.1 ± 0.4* |
| Fasting FFAs (μmol/l) | 351 ± 37 | 479 ± 59* | 750 ± 29*† |
| FFA AUC during OGTT (μmol/l · 2 h) | 22.8 ± 1.1 | 31.3 ± 3.3* | 55.9 ± 3.7*† |
| TNF-α (pg/ml) | 1.26 ± 0.10 | 1.63 ± 0.30 | 2.13 ± 0.32* |
| IL-6 (pg/ml) | 1.17 ± 0.15 | 1.91 ± 0.40 | 2.42 ± 0.33* |
Data are means ± SE.
*
P < 0.05 vs. lean;
†
P < 0.05 vs. obese.