FIG. 2.

Glucose turnover and glycogen synthesis rates. A: Whole-body glucose turnover, glycolysis, and glycogen synthesis rates (mg · kg⁻¹ · min⁻¹). Glycogen synthesis rates (pg · mg⁻¹ · min⁻¹) in liver (B) and muscle (C) were assessed after a 2-h water or glucose intragastric infusion (protocol 1) in wild-type and GLP-1Rc knockout (GLP-1Rc KO) mice (see protocol 1 in Fig. 1). A subset of wild-type mice was infused simultaneously with Ex9 into the brain (Ex9). Five to nine mice per group were studied. *Statistically different from water-infused control mice when P < 0.05.