FIG. 2.
Diabetes causes a decrease in OGG1 protein expression and increases 8-oxodG levels. A: Kidney cortex sections were stained with anti-OGG1 antibody. There is a decrease in OGG1 staining in kidney cortex of diabetic animals compared with the controls. B: 8-OxodG levels are higher in mitochondrial DNA fraction of kidney cortex of diabetic rats compared with control rats. Data are expressed as picomoles 8-oxodG/dG × 10−5 in 90 μl DNA hydrolysate. Significant difference from wild-type cells is indicated by **P < 0.01. (Please see http://dx.doi.org/10.2337/db07-1579 for a high-quality digital representation of this image.)