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. 2008 Oct;57(10):2626–2636. doi: 10.2337/db07-1579

FIG. 4.

FIG. 4.

Role of PI 3-kinase activation by high glucose (HG) on OGG1 expression in MCT cells. A and C: Representative immunoblot shows a decrease in phospho-Akt (p-Akt) expression in cells preincubated with 50 μmol/l LY294002 and 100 nmol/l Wortmannin, respectively, before exposure to high glucose for 60 min. B and D: Representative immunoblot shows an increase in OGG1 expression in cells preincubated with 50 μmol/l LY294002 and 100 nmol/l Wortmannin before exposure to high glucose for 60 min. Histograms in the bottom panel represent means ± SE of three independent experiments. Significant difference from nontreated cells is indicated by *P < 0.05 and **P < 0.01. NG, normal glucose.