TABLE 2.

Tight glucose control in 4-month diabetic rats normalizes the rate of body weight gain and GHb levels but only partially ameliorates tactile allodynia

	Body wt (g)	GHb (%)	50% Withdrawal thresholds (g)
Normal/8 months	535 ± 46	3.7 ± 0.1	13.80 ± 2.03
Poor glucose control–diabetic/8 months	270 ± 28*	9.5 ± 0.7*	3.04 ± 0.9†
Poor glucose control–diabetic/4 months (before insulin treatment)	308 ± 39	9.9 ± 1.6	2.92 ± 0.89
Tight glucose control–diabetic/4 months (after insulin treatment)	403 ± 44‡	4.9 ± 0.2‡	6.76 ± 1.46†§

Data are means ± SD of 6–10 animals. Four-month diabetic rats (poor glucose control–diabetic/4 months) were either left untreated for an additional 4 months (poor glucose control–diabetic/8 months) or subjected to tight glucose control for 4 months (tight glucose control–diabetic/4 months). The presence of tactile allodynia was evaluated as indicated in the legend to Fig. 1.

^*Significantly different from normal rats at P < 0.01 (Student's t test).

^‡Significantly different from poor glucose control–diabetic/4 months at P < 0.01 (paired Student's t test). Significantly different from

^†normal and

^§poor glucose control–diabetic/4 months at P < 0.01 (Kruskal-Wallis test, followed by Dunn's test).