TABLE 3.

Effects of sulfasalazine and PJ34 on mechanical hyperalgesia in experimentally diabetic rats

	Mechanical hyperalgesia withdrawal threshold (g)
	6 months	9 months
Normal	218 ± 50	198 ± 4
Diabetic	71 ± 3*	87 ± 7*
Diabetic + sulfasalazine	111 ± 14*	133 ± 34
Diabetic + PJ34	ND	63 ± 5*

Data are means ± SE of four to eight animals.

^*Significantly different from normal rats at P < 0.01 (ANOVA, followed by Dunnett's test). The statistical analysis showed no significant differences when comparing the diabetic + sulfasalazine or diabetic + PJ34 with the untreated diabetic rats; however, the diabetic + sulfasalazine withdrawal thresholds at 9 months were not significantly different than those in normal rats. ND, not determined.