TABLE 2.
Association between nine FTO SNPs with obesity, risk of type 2 diabetes, and impaired fasting glucose/impaired glucose tolerance (IFG/IGT) in the NHS98 and SiMES populations
| SNP | rs9939973 | rs9940128 | rs1421085 | rs1121980 | rs7193144 | rs17817449 | rs8050136 | rs9926289 | rs9939609 |
|---|---|---|---|---|---|---|---|---|---|
| NHS98 Chinese (n = 2,919) | |||||||||
| ΔBMI per risk allele present (kg/m2) | 0.43 | 0.42 | 0.68 | 0.43 | 0.63 | 0.67 | 0.68 | 0.68 | 0.66 |
| P*/P† | <0.0001/<0.0001 | 0.001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 |
| Glucose tolerance | |||||||||
| OR (95% CI)* for type 2 diabetes vs. NGT | 1.33 (1.01–1.74) | 1.32 (1.00–1.72) | 1.42 (1.04–1.93) | 1.19 (0.91–1.53) | 1.42 (1.04–1.92) | 1.39 (1.01–1.90) | 1.40 (1.02–1.90) | 1.40 (1.02–1.90) | 1.37 (1.00–1.86) |
| P*/P† | 0.036/0.132 | 0.043/0.15 | 0.024/0.128 | 0.187/0.434 | 0.025/0.102 | 0.039/0.178 | 0.036/0.168 | 0.035/0.163 | 0.049/0.212 |
| OR (95% CI) for IFG/IGT vs. NGT* | 1.10 (0.91–1.32) | 1.09 (0.90–1.31) | 1.15 (0.92–1.42) | 1.08 (0.90–1.29) | 1.10 (0.89–1.37) | 1.14 (0.91–1.41) | 1.14 (0.91–1.40) | 1.14 (0.92–1.41) | 1.12 (0.89–1.38) |
| P*/P† | 0.323/0.527 | 0.338/0.546 | 0.197/0.503 | 0.368/0.702 | 0.366/0.729 | 0.241/0.578 | 0.25/0.611 | 0.223/0.568 | 0.313/0.684 |
| NHS98 Malay (n = 785) | |||||||||
| ΔBMI per risk allele present (kg/m2) | 0.83 | 0.82 | 0.90 | 0.65 | 0.82 | 0.91 | 0.86 | 0.88 | 0.89 |
| P*/P† | 0.001/0.002 | 0.002/0.002 | 0.001/0.001 | 0.011/0.015 | 0.002/0.002 | 0.001/0.001 | 0.001/0.002 | 0.001/0.001 | 0.001/0.001 |
| Glucose tolerance | |||||||||
| OR (95% CI)* for type 2 diabetes vs. NGT | 1.61 (1.10–2.33) | 1.60 (1.09–2.32) | 1.59 (1.09–2.32) | 1.57 (1.08–2.25) | 1.52 (1.04–2.21) | 1.63 (1.11–2.38) | 1.53 (1.04–2.24) | 1.60 (1.09–2.32) | 1.57 (1.08–2.29) |
| P*/P† | 0.013/0.082 | 0.014/0.084 | 0.016/0.095 | 0.016/0.071 | 0.027/0.12 | 0.011/0.074 | 0.028/0.129 | 0.015/0.092 | 0.018/0.104 |
| OR (95% CI) for IFG/IGT vs. NGT* | 1.34 (1.03–1.74) | 1.35 (1.03–1.74) | 1.22 (0.93–1.58) | 1.37 (1.06–1.77) | 1.21 (0.93–1.57) | 1.25 (0.95–1.63) | 1.20 (0.91–1.56) | 1.24 (0.95–1.61) | 1.22 (0.93–1.59) |
| P*/P† | 0.028/0.075 | 0.025/0.067 | 0.144/0.331 | 0.015/0.033 | 0.154/0.331 | 0.103/0.243 | 0.186/0.392 | 0.113/0.267 | 0.136/0.318 |
| NHS98 Asian-Indians (n = 594) | |||||||||
| ΔBMI per risk allele present (kg/m2) | 0.24 | 0.23 | 0.03 | 0.28 | 0.12 | 0.10 | 0.04 | 0.11 | 0.10 |
| P*/P† | 0.352/0.333 | 0.36/0.347 | 0.913/0.781 | 0.267/0.247 | 0.658/0.458 | 0.715/0.527 | 0.877/0.719 | 0.674/0.487 | 0.7/0.532 |
| Glucose tolerance | |||||||||
| OR (95% CI)* for type 2 diabetes vs. NGT | 0.84 (0.59–1.19) | 0.85 (0.59–1.20) | 0.87 (0.60–1.25) | 0.94 (0.66–1.31) | 0.93 (0.64–1.32) | 0.85 (0.58–1.23) | 0.87 (0.60–1.24) | 0.88 (0.61–1.27) | 0.96 (0.67–1.37) |
| P*/P† | 0.341/0.356 | 0.349/0.365 | 0.467/0.564 | 0.711/0.74 | 0.677/0.766 | 0.393/0.438 | 0.445/0.53 | 0.51/0.543 | 0.84/0.914 |
| OR (95% CI) for IFG/IGT vs. NGT* | 0.95 (0.69–1.29) | 0.96 (0.70–1.30) | 0.90 (0.65–1.24) | 1.05 (0.77–1.41) | 0.88 (0.63–1.21) | 0.85 (0.60–1.17) | 0.91 (0.66–1.25) | 0.87 (0.62–1.20) | 0.87 (0.63–1.20) |
| P*/P† | 0.754/0.707 | 0.775/0.732 | 0.515/0.509 | 0.774/0.895 | 0.432/0.404 | 0.327/0.294 | 0.576/0.565 | 0.411/0.378 | 0.419/0.369 |
| SiMES Malay | |||||||||
| ΔBMI per risk allele present (kg/m2) | 0.55 | 0.55 | 0.64 | 0.52 | 0.62 | 0.64 | 0.63 | 0.61 | 0.64 |
| P*/P† | <0.0001/<0.0001 | 0.001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 | <0.0001/<0.0001 |
| Glucose tolerance | |||||||||
| OR (95% CI)* for type 2 diabetes vs. NGT | 1.23 (1.08–1.40) | 1.24 (1.08–1.40) | 1.20 (1.05–1.37) | 1.24 (1.08–1.40) | 1.21 (1.05–1.37) | 1.20 (1.05–1.37) | 1.20 (1.05–1.37) | 1.20 (1.05–1.37) | 1.21 (1.05–1.38) |
| P*/P† | 0.001/0.004 | 0.001/0.004 | 0.007/0.025 | 0.001/0.003 | 0.005/0.019 | 0.007/0.026 | 0.007/0.023 | 0.006/0.021 | 0.005/0.019 |
*
Adjusted for age and sex;
†
adjusted for age, sex, current smoking, exercise (except in the SiMES population), BMI (for risk of type 2 diabetes), education, and alcohol consumption. NGT, normal glucose tolerance.