TABLE 3.

Association of FTO SNP rs9939609 with obesity-related traits in the NHS98 and SiMES populations

	1998 Singapore National Health Study (NHS98)															Singapore Malay Eye Study (SiMES)
	Chinese (n = 2,919)					Malay (n = 785)					Asian Indians (n = 594)					SiMES Malay (n = 2,996)
	0	1	2	P*	P†	0	1	2	P*	P†	0	1	2	P*	P†	0	1	2	P*	P†
HDL cholesterol (mmol/l)	1.42	1.42	1.42	0.735	0.127	1.31	1.29	1.27	0.244	0.792	1.15	1.14	1.14	0.832	0.741	1.36	1.34	1.33	0.164	0.785
LDL cholesterol (mmol/l)	3.36	3.44	3.52	0.024	0.298	3.87	3.86	3.84	0.787	0.248	3.70	3.70	3.70	0.787	0.939	3.52	3.55	3.58	0.251	0.508
Triglycerides (mmol/l)	1.18	1.18	1.17	0.813	0.037	1.37	1.44	1.52	0.062	0.522	1.42	1.43	1.44	0.876	0.833	1.25	1.26	1.27	0.752	0.955
Waist (cm)	77.84	79.09	80.35	<0.0001	<0.0001	81.70	83.56	85.42	0.001	0.002	84.97	85.17	85.38	0.74	0.775		NA		—	—
Waist-to-hip ratio	0.82	0.83	0.83	0.184	0.174	0.83	0.83	0.84	0.198	0.202	0.86	0.85	0.85	0.584	0.597		NA		—	—
Systolic BP (mmHG)	120.6	121.0	121.4	0.49	0.641	124.3	125.4	126.5	0.236	0.835	120.6	121.7	122.9	0.194	0.175	147.0	147.4	147.7	0.541	0.949
Diastolic BP (mmHG)	73.6	74.2	74.7	0.179	0.79	75.7	76.7	77.7	0.108	0.995	72.7	74.1	75.6	0.039	0.027	79.9	79.8	79.6	0.56	0.308

Genotypes 0, 1, and 2 represent numbers of risk/minor alleles, which correspond with risk alleles in previous studies in Europeans.

^*Adjusted for age and sex;

^†adjusted for age, sex, current smoking, exercise (except in SiMES), BMI (where appropriate), education, and alcohol consumption. BP, blood pressure; IFG/IGT, impaired fasting glucose/impaired glucose tolerance; NA, not applicable; NGT, normal glucose tolerance.