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. 2008 Sep 12;415(Pt 1):135–144. doi: 10.1042/BJ20080435

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© 2008 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The two branches of the Kennedy pathway are (a) the CDP-choline pathway and (b) the CDP-ethanolamine pathway. The relevant steps are discussed in the text. CK, choline kinase (Tb11.18.0017/Tb927.5.1140); CCT, CTP:phosphocholine cytidyltransferase (Tb10.389.0730); CPT, diacylglycerol:CDP-choline cholinephosphotransferase (Tb10.6k15.1570); EK, ethanolamine kinase (Tb11.18.0017/Tb927.5.1140); ECT, CTP:phosphoethanolamine cytidyltransferase (Tb11.01.5730); EPT, diacylglycerol:CDP-ethanolamine ethanolaminephosphotransferase (Tb10.6k15.1570); PSD, phosphatidylserine decarboxylase (Tb09.211.1610); PEMT, phosphatidylethanolamine methyltransferases; DAG, diacylglycerol. The dashed box indicates methyltransferase enzymes which are not present in either T. brucei or T. cruzi, but are present in L. major.