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. Author manuscript; available in PMC: 2008 Sep 24.
Published in final edited form as: J Biol Chem. 2004 Oct 15;279(53):55780–55791. doi: 10.1074/jbc.M406480200

Fig. 10. Proposed topology of the cleavage and modification of the 1-phosphate group of H. pylori lipid A.

Fig. 10

After assembly of Kdo2-lipid A bearing the core oligosaccharide (core-lipid A), the macromolecule is transported across the inner membrane by the ABC transporter, MsbA (28, 67). In H. pylori, the 1-phosphate group of the lipid A domain can then be removed by a specific phosphatase Hp0021. This is followed by the addition of a pEtN unit directly to the glucosamine disaccharide backbone catalyzed by the lipid A pEtN transferase, Hp0022. The predicted membrane topology of Hp0021 and Hp0022 was determined using the program SOSUI (sosui.proteome.bio.tuat.ac.jp/sosuiframe0.html) (75, 76).