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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Mol Pharmacol. 2008 Apr 18;74(1):203–212. doi: 10.1124/mol.108.044891

Figure 7. The effects of GABA, muscimol, pentobarbital and SR-95531 on MTSEA-Biotin second order rate constants.

Figure 7

Second-order rate constants for MTSEA-Biotin modification ofα1H101C in the absence (control) and presence of GABA (EC95), muscimol (EC95), pentobarbital (PENTO, 500 μM) and SR-95531 (IC95) were measured as described in “Experimental Procedures”. Rate constants for both the decrease in BZD potentiation (α/γ) and the increase in I-GABA (α/β) were measured and normalized to the MTSEA-Biotin reaction rates measured in the absence of these ligands (control, dashed line). Data represent mean ±SD from at least 3 experiments. * Significantly different from control (p < 0.05). k2 values are shown in Table 3.