Skip to main content
. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Mol Pharmacol. 2008 Apr 18;74(1):203–212. doi: 10.1124/mol.108.044891

Table 2.

Second order rate constants (k2) for decreases in BZD potentiation and changes in I-GABA following MTSEA-biotin modification of mutant receptors.

Receptor BZD Potentation k2 (M−1 s−1) n I-GABA k2 (M−1 s−1) n
α1 D97C β2 γ2 20.5 ± 5.7 6
α1 H101C β2 γ2 2194.6 ± 354.1 6 122.3 ± 10.8* 5
α1 N102C β2 γ2 46.7 ± 5.5 7 52.9 ± 22.1 8
α1 S106C β2 γ2 28.9 ± 8.2 6 11.3 ± 3.9* 7
α1 H101C β2 121.4 ± 40.4 5

The concentrations of MTSEA-Biotin used were variable depending on the mutant and are listed under “Experimental Procedures”. Values are mean ± SD.

*

Indicates the decrease in BZD potentiation was significantly faster that the increase in I-GABA (p<0.05) for that receptor.