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letter
. 1980 Feb;72(2):127–131.

Hyperthyroidism and Ulcerative Colitis: Report of Two Cases and a Review of the Literature

Swaminath K Iyer, Robyn G Karlstadt
PMCID: PMC2552470  PMID: 7365812

Abstract

Two cases of coexisting ulcerative colitis and hyperthyroidism are discussed. In both patients, thyrotoxicosis preceded the development of the ulcerative colitis. Exacerbations of the thyroid disease led to exacerbations of ulcerative colitis and consequent difficulty in the management of the patients. Although a review of the literature reveals a possible connection with abnormalities of iodine metabolism in the ulcerative colitis patient, no definite conclusions are drawn.

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Selected References

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  1. Clubb J. S., Black P. J., Wallace D. C. An association of thyroid disease, ulcerative colitis and diabetes mellitus. Report of three cases in young women. Australas Ann Med. 1970 May;19(2):159–164. doi: 10.1111/imj.1970.19.2.159. [DOI] [PubMed] [Google Scholar]
  2. EDWARDS F. C., TRUELOVE S. C. THE COURSE AND PROGNOSIS OF ULCERATIVE COLITIS. III. COMPLICATIONS. Gut. 1964 Feb;5:1–22. doi: 10.1136/gut.5.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hellesen C., Friis T., Larsen E., Pock-Steen C. Small intestinal histology, radiology and absorption in hyperthyroidism. Scand J Gastroenterol. 1969;4(2):169–175. doi: 10.3109/00365526909179925. [DOI] [PubMed] [Google Scholar]
  4. Hodgson H. J., Jewell D. P. The humoral immune system in inflammatory bowel disease. II. Immunologlobulin levels. Am J Dig Dis. 1978 Feb;23(2):123–128. doi: 10.1007/BF01073186. [DOI] [PubMed] [Google Scholar]
  5. Hodgson H. J., Potter B. J., Jewell D. P. Humoral immune system in inflammatory bowel disease: I. Complement levels. Gut. 1977 Sep;18(9):749–753. doi: 10.1136/gut.18.9.749. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hodgson H. J., Potter B. J., Jewell D. P. Immune complexes in ulcerative colitis and Crohn's disease. Clin Exp Immunol. 1977 Aug;29(2):187–196. [PMC free article] [PubMed] [Google Scholar]
  7. Järnerot G., Azad Khan A. K., Truelove S. C. The thyroid in ulverative colitis and Crohn's disease. II. Thyroid enlargement and hyperthyroidism in ulcerative colitis. Acta Med Scand. 1975 Jan-Feb;197(1-2):83–87. doi: 10.1111/j.0954-6820.1975.tb04882.x. [DOI] [PubMed] [Google Scholar]
  8. Järnerot G. The thyroid in ulcerative colitis and Crohn's disease. I. Thyroid radioiodide uptake and urinary iodine excretion. Acta Med Scand. 1975 Jan-Feb;197(1-2):77–81. doi: 10.1111/j.0954-6820.1975.tb04881.x. [DOI] [PubMed] [Google Scholar]
  9. Järnerot G., Truelove S. C., von Schenck H. The thyroid in ulcerative colitis and Crohn's disease. IV. Thyroid hormone binding proteins. Acta Med Scand. 1975 Jan-Feb;197(1-2):95–98. doi: 10.1111/j.0954-6820.1975.tb04884.x. [DOI] [PubMed] [Google Scholar]
  10. Järnerot G., Truelove S. C., von Schenck H. The thyroid in ulcerative colitis and Crohn's disease. IV. Thyroid hormone binding proteins. Acta Med Scand. 1975 Jan-Feb;197(1-2):95–98. doi: 10.1111/j.0954-6820.1975.tb04884.x. [DOI] [PubMed] [Google Scholar]
  11. Miller L. J., Gorman C. A., Go V. L. Gut-thyroid interrelationships. Gastroenterology. 1978 Nov;75(5):901–911. [PubMed] [Google Scholar]
  12. NADLER S. H., MOORE G. E. AUTOTRANSPLANTATION OF HUMAN CANCER. JAMA. 1965 Jan 11;191:105–106. doi: 10.1001/jama.1965.03080020033009. [DOI] [PubMed] [Google Scholar]
  13. Palmer H. M., Beardwell C. G. Hyperthyroidism presenting with acute abdominal symptoms. Practitioner. 1974 Feb;212(1268):239–243. [PubMed] [Google Scholar]
  14. Powell J. R., Shapiro H. A., Carbone J. V. Therapeutic problems of ulcerative colitis with hyperthyroidism. Am J Gastroenterol. 1968 Aug;50(2):116–124. [PubMed] [Google Scholar]
  15. Sheehy T. W., Allison T. M. Apathetic thyrotoxicosis causing gastrointestinal malabsorption. JAMA. 1974 Oct 7;230(1):69–71. [PubMed] [Google Scholar]
  16. Souadjian J. V., Enriquez P., Silverstein M. N., Pépin J. M. The spectrum of diseases associated with thymoma. Coincidence or syndrome? Arch Intern Med. 1974 Aug;134(2):374–379. [PubMed] [Google Scholar]
  17. THAYER W. R., Jr, SPIRO H. M. Protein abnormalities in ulcerative colitis patients and their families. Gastroenterology. 1963 Apr;44:444–447. [PubMed] [Google Scholar]
  18. Thomas F. B., Caldwell J. H., Greenberger N. J. Steatorrhea in thyrotoxicosis. Relation to hypermotility and excessive dietary fat. Ann Intern Med. 1973 May;78(5):669–675. doi: 10.7326/0003-4819-78-5-669. [DOI] [PubMed] [Google Scholar]
  19. WETTERFORS J., LILJEDAHL S. O., PLANTIN L. O., BIRKE G. HYPOALBUMINAEMIA IN ULCERATIVE COLITIS AND CERTAIN FORMS OF ENTERITIS. CLINICAL AND PATHOPHYSIOLOGICAL ASPECTS. Acta Med Scand. 1963 Nov;174:529–549. doi: 10.1111/j.0954-6820.1963.tb07953.x. [DOI] [PubMed] [Google Scholar]
  20. Weigle W. O., Nakamura R. M., Spiegelberg H. L., Golub E. S., High G. J. Autoimmunity and termination of immunological unresponsiveness. Arch Pathol. 1967 Dec;84(6):647–658. [PubMed] [Google Scholar]
  21. Wright R., Truelove S. C. Auto-immune reactions in ulcerative colitis. Gut. 1966 Feb;7(1):32–40. doi: 10.1136/gut.7.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]

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