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Inhibitors of the INK4 family prevent phosphorylation of cdk6 by p40MO15 but not by Cak1p. GST-cdk6 (A and C) or cdk2 (B and D) was phosphorylated directly by GST-Cak1p (upper panels) or by p40MO15/cyclin H (lower panels) in the presence of various concentrations of p16 (A and B) or GST-p18 (C and D). Lanes 1 contained no inhibitors. Mass ratios of cdk:inhibitor are as in Figure 6. In all experiments the cdk:cyclin A173–432 ratio was chosen to be 1:0.75.
