Abstract
The influence of differential washout on the redistribution phenomenon of thallium 201 chloride deposited in ischemic myocardium was investigated. Two groups of dogs had serial scintigraphic images and tissue counting performed. The first group had ischemia produced prior to the injection of the thallium and, following the control image after production of ischemia, the occlusion was released and serial images obtained over a three-hour period. The second group received thallium initially and after a control scintigraph was taken, ischemia was created and maintained for three hours via transthoracic ligature. Activity distribution was followed by serial images. Thallium content of ischemic areas was compared to the normal area by computer assisted data analysis. Tissues from the ischemic and normal areas from both groups were obtained after the serial images and counted. In the first group, prompt redistribution of activity into the ischemic areas was seen within 30 minutes of releasing the occlusion and was verified by tissue counting. Neither scintigraphic image changes nor tissue uptake differences were observed in the second group. The restoration of blood flow and consequently increased avidity for thallium probably accounted for the redistribution seen in the first group as there appeared to be no differential washout of activity in the second group from either the ischemic or normal areas to contribute to the redistribution phenomenon.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bailey I. K., Griffith L. S., Rouleau J., Strauss W., Pitt B. Thallium-201 myocardial perfusion imaging at rest and during exercise. Comparative sensitivity to electrocardiography in coronary artery disease. Circulation. 1977 Jan;55(1):79–87. doi: 10.1161/01.cir.55.1.79. [DOI] [PubMed] [Google Scholar]
- Botvinick E. H., Taradash M. R., Shames D. M., Parmley W. W. Thallium-20 1 myocardial perfusion scintigraphy for the clinical clarification of normal, abnormal and equivocal electrocardiographic stress tests. Am J Cardiol. 1978 Jan;41(1):43–51. doi: 10.1016/0002-9149(78)90130-3. [DOI] [PubMed] [Google Scholar]
- Lenaers A., Block P., Thiel E. V., Lebedellr M., Becquevort P., Erbsmann F., Ermans A. Segmental analysis of Ti-201 stress myocardial scintigraphy. J Nucl Med. 1977 Jun;18(6):509–516. [PubMed] [Google Scholar]
- Pohost G. M., Zir L. M., Moore R. H., McKusick K. A., Guiney T. E., Beller G. A. Differentiation of transiently ischemic from infarcted myocardium by serial imaging after a single dose of thallium-201. Circulation. 1977 Feb;55(2):294–302. doi: 10.1161/01.cir.55.2.294. [DOI] [PubMed] [Google Scholar]
- Ritchie J. L., Albro P. C., Caldwell J. H., Trobaugh G. B., Hamilton G. W. Thallium-201 myocardial imaging: a comparison of the redistribution and rest images. J Nucl Med. 1979 Jun;20(6):477–483. [PubMed] [Google Scholar]
- Ritchie J. L., Trobaugh G. B., Hamilton G. W., Gould K. L., Narahara K. A., Murray J. A., Williams D. L. Myocardial imaging with thallium-201 at rest and during exercise. Comparison with coronary arteriography and resting and stress electrocardiography. Circulation. 1977 Jul;56(1):66–71. doi: 10.1161/01.cir.56.1.66. [DOI] [PubMed] [Google Scholar]
- Schwartz J. S., Ponto R., Carlyle P., Forstrom L., Cohn J. N. Early redistribution of thallium-201 after temporary ischemia. Circulation. 1978 Feb;57(2):332–335. doi: 10.1161/01.cir.57.2.332. [DOI] [PubMed] [Google Scholar]
- Strauss H. W., Harrison K., Langan J. K., Lebowitz E., Pitt B. Thallium-201 for myocardial imaging. Relation of thallium-201 to regional myocardial perfusion. Circulation. 1975 Apr;51(4):641–645. doi: 10.1161/01.cir.51.4.641. [DOI] [PubMed] [Google Scholar]
- Verani M. S., Marcus M. L., Razzak M. A., Ehrhardt J. C. Sensitivity and specificity of thallium-201 perfusion scintigrams under exercise in the diagnosis of coronary artery disease. J Nucl Med. 1978 Jul;19(7):773–782. [PubMed] [Google Scholar]