Table 2.
Clusters of significant brain response within the inferior frontal gyrus search region for the contrast of New pairs vs. fixation
| Direction of Response | Hemisphere | Subregion (Brodmann’s Area) | Volume (in μl) | Coordinates of Maximum Intensity Voxel | T-score for Maximum Intensity Voxel | Eta2 (Mean ± SEM) |
|---|---|---|---|---|---|---|
| HC Participants | ||||||
| Learn > Fixation | ||||||
| L | Dorso- and ventro-lateral (9,44,45 & 47) | 17664 | 47L, 19A, 14S | 7.6 | 0.46 ± 0.01 | |
| R | Dorsolateral (9 & 44) | 4032 | 49R, 5A, 26S | 5.9 | 0.48 ± 0.02 | |
| Schizophrenia Patients | ||||||
| Learn > Fixation | ||||||
| L | Dorsolateral (9 & 44) | 4928 | 49L, 9A, 26s | 5.1 | 0.37 ± 0.01 | |
| R | Dorsolateral (9 & 44) | 1472 | 46R, 3A, 27S | 3.2 | 0.29 ± 0.01 | |
| Fixation > Learn | ||||||
| R | Ventrolateral (47) | 1728 | 34L, 17A, 13I | -5.9 | -0.38 ± 0.02 | |
| HC > Schizophrenia | ||||||
| *L | Ventrolateral (45) | 4480 | 46L, 30A, 7S | 3.9 | 0.21 ± 0.01 | |
| L | Ventrolateral (47) | 2432 | 31L, 24A, 9I | 4.0 | 0.23 ± 0.01 | |
| *R | Ventrolateral (47) | 1920 | 35R, 17A, 13I | 3.8 | 0.20 ± 0.01 |
Note: L = Left, R= Right, A = Anterior, P = Posterior, S = Superior, I = Inferior,
*
=Brain response correlated with recall performance among patients at trend level (r’s = 0.38)