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. 2007 Aug 29;70(3):834–843. doi: 10.1002/prot.21612

Table III.

Estimated Time in Minutes Required to Generate 10,000 Closed and Sterically Feasible Loop Conformations

Tusablea
Algorithm Eight Eleven Twelve
Random Tweak 1.99 8.47 10.17
CCDb 159.46 511.10 527.77
Wriggling 5.67 28.50 22.50
PLOP-build 3.39 35.00 71.67
Direct Tweak 34.00 73.44 75.65
LOOPYbb 22.86 62.21 59.15
a

See Equation 1.

b

The implementation of Canutescu and Dunbrack24 is about seven times faster.