Fig. 1.

Agonist-directed feeding behavior in CCR5 transgenic animals. Bacterial colonies expressing MIP-1α (pSANG10-MIP-1α) or a control protein (pSANG10-scFv) were grown side-by-side in the two configurations described. Transgenic worms were placed in the center of the plate (marked with X) at equal distance from the bacterial colonies. The percentage associated with each colony was plotted. In the optimal configuration (colonies grown close together and worms prefed with standard OP50 bacteria), >70% of the transgenic animals prefer to graze on the ScFv-expressing colonies, compared with 20% that are distributed over the MIP-1α-expressing bacteria. (P ≤ 0.001; SEM for CCR5 transgenic and wild-type animals, 1.15 and 2.86, respectively.) Photograph shows the grazing animals from a pair of colonies in the closer configuration after 45 min.