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. 2008 Sep 12;27(1):37. doi: 10.1186/1756-9966-27-37

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Copyright © 2008 Kucukzeybek et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Changes in mRNA levels of apoptosis related genes in DU-145 cells exposed to docetaxel and ATRA combination as compared to untreated controls. mRNA profiles of apoptosis related genes were obtained by using Oligo GEArray Human Apoptosis (SuperArray, Frederick, MD, USA). mRNAs were isolated from untreated, docetaxel treated, ATRA treated and combination of docetaxel and ATRA treated DU-145 cells. Survivin (BIRC5), MLC-1 and LTβR mRNA levels were significantly downregulated by combination treatment. P < 0,05 was considered significant.