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The frequency of variant amino acids in Interhelical Domain II of Vpr (Residues 51 – 54)
| Residue | Residues in NL4-3 Vpr | Variant residue(s) noted in viruses of subtype B |
| 51 | G | E (0.7), K (0.4) |
| 52 | D | N (0.7), I (0.4) |
| 53 | T | A (0.4), L (0.4) |
| 54 | W | R (0.4), G (0.4) |
