Table 4.

Top SNPs ranked by univariate analysis for trial E9486.

Rank	rs ID	pval	Gene Sym	Gene Name	SNP Function
1.0	rs10018625	0.001536	TAG ERROR	TAG ERROR	unknown, TAG ERROR
2.0	rs1047643	0.001603	FDFT1	Farnesyl-diphosphate farnesyltransferase 1	coding-synon
3.0	rs20541	0.001644	IL13	Interleukin 13	coding-nonsynon
4.0	rs2108622	0.0020374	CYP4F2	Cytochrom P450, family 4, subfamily F, polypeptide 2	coding-nonsynon
5.0	rs3759259	0.002362	STYK1	Protein kinase STYK1	coding-nonsynon
6.0	rs1801133	0.003251	MTHFR	5, 10-methylenetetrahydrofolate reductase (NADPH)	coding-nonsynon
7.0	rs2069456	0.003375	CDK5	Cyclin-dependent kinase 5	intron
8.0	rs1131532	0.005650	TNFSF10	Tumor necrosis factor (ligand) superfamily, member 10	coding-synon
9.0	rs882709	0.005965	SETX	senataxin	coding-nonsynon
10.0	rs4646421	0.007847	CYP1A1	Cytochrome P450, family 1, subfamily A, polypeptide 1	intron
11.0	rs1799969	0.008221	ICAM1	Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor	coding-nonsynon
12.0	rs3822430	0.009157	SRD5A1	Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	coding-synon
13.0	rs7903344	0.009471	CHUK	Conserved helix-loop-helix ubiquitous kinase	coding-nonsynon
14.0	rs13926	0.011531	TRAP1	TNF receptor-associated protein 1	coding-nonsynon
15.0	rs3172469	0.012006	BCL6	B-cell CCL/lymphoma 6 (zinc finger protein 51)	intron
16.0	rs215101	0.012028	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	intron, TagSNP:ABCC1
17.0	rs2227564	0.012246	PLAU	Plasminogen activator, urokinase	coding-nonsynon
18.0	rs3096057	0.012484	CSF1	Colony stimulating factor 1 (macrophage)	Promoter
19.0	rs6474491	0.013935	STAR	Steriodogenic acute regulator	Promoter
20.0	rs2066471	0.015231	MTHRF	5, 10-methlyenetetrahydrofolate reductase (NADPH)	intron