FIGURE 3.

Schematics for the developmental models and their modifications. Models 1 and 2 were used in backbone model development. Models 3–6 represent the original four permutations of models containing explicit BiP and PDI binding and release. When Modification A was applied to these models, they were designated Models 3*−6*, which are not schematized here. Model 7 represents a binding permutation model where the branched dependency-degradation competition motif for BiP was introduced by eliminating BiP's role in post-translational translocation. Model 8 depicts a final permutation where UscFv may freely move between BiP and PDI binding states and has Modification A implemented in it. The figure legend that defines species, prefixes, icons, and rate constant subscript prefixes and suffixes is in Table 2. Parameter definitions and values are in Table 3.