FIGURE 8.

Plots demonstrating SscFv production dependency on the rate at which cytoplasmic UscFv was trafficked to the translocon (k₅₈) for double BiP and PDI (A), triple BiP and PDI (B), and quadruple BiP and PDI (C) overexpression levels. SscFv levels were measured at 50 h and compared to the experimental values (dashed lines). Error bars for the experimental data are provided on one experimental data point for ease of interpretation but apply to all: O.BiP+PDI and O.BiP error bars are found at O.PDI, at and nominal, at