TABLE 3.

Average number of H-bonds (rounded to nearest integer) between TRH (hydroxyl groups) and either the phosphate or ester groups of lipid molecules during the simulations of a hydrated DPPC bilayer at 325 K with different negative lateral pressures in a 2-m TRH solution

Simulation	Px,Py (bar)	H-bonds to phosphate	H-bonds to ester	H-bonds to phosphate (%)	H-bonds to ester (%)
At	1	102	15	87	13
Bt	−100	114	47	71	29
Ct	−150	126	97	57	43
Dt	−200	122	106	54	46
Et	−250	137	128	52	48

Relative contributions (in percentages) to the total number of TRH-DPPC H-bonds are also presented. Values are averaged over the final 10 ns of the simulations. See legend of Table 2 for the H-bonding criteria. See Table 1 for the simulation codes.