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Shear topology is a common feature of mechanically stable proteins. Images A–D show the three-dimensional structures of representative proteins that are mechanically stable and possess shear topology: (A) I27, (B) ubiquitin, (C) the 10th FnIII domains of fibronectin, and (D) GB1. For comparison, the three-dimensional structure of C2A, which is mechanically weak and possesses a typical unzipping topology, is shown in E.
