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. 2008 Oct 1;3(10):e3299. doi: 10.1371/journal.pone.0003299

Figure 1. Protein interactions of SARS-CoV detected by mammalian two-hybrid assays.

Figure 1

(A) Interaction matrix of SARS-CoV proteins. The grey squares indicate the novel interactions detected in this work. The black squares represent the interactions which have also been reported previously, including nsp5–nsp5[19], [68], [69], nsp5–nsp7 and nsp8[9], nsp7–nsp7[21], [70], nsp7–nsp8[21], nsp7–nsp9[9], nsp8–9b[9], nsp10–nsp14 and nsp10–nsp16[10], nsp15–nsp15 [54], [56], [71], [72], nsp7-E and 7a-M[73], N-N[55], [57] and N-N[55], [57]. (B) A typical result for a positive interaction with the example of nsp10–nsp14. The combination of pM-53 and pVP16-T represents a positive control. (C) A typical interaction inhibition assay performed to confirm that the interaction was not resulted from self-activation. Error bars represent standard deviations from three independent experiments.