Table 2.

Functions associated with the top five networks for genes whose translation state was affected by radiation for each tumor type

	Score	Focus molecules	Top functions
Breast
1	40	34	Gene expression, cell cycle, DNA replication, recombination, and repair
2	40	34	Cellular development, cancer, cell cycle
3	35	32	Cell-to-cell signaling and interaction, nervous system development and function, cancer
4	33	31	Small molecule biochemistry, cell morphology, cancer
5	33	31	Cell cycle, cellular assembly and organization, cellular movement
Lung
1	53	35	Viral function, cancer, hematologic disease
2	38	29	Cardiovascular system development and function, cellular growth and proliferation, cellular movement
3	38	29	Cancer, cell death, hematologic disease
4	38	29	Neurologic disease, cancer, reproductive system disease
5	38	29	Cancer, endocrine system disorders, cell cycle
Glioma
1	32	35	Cancer, embryonic development, organ development
2	32	35	Cell death, cancer, cell morphology
3	32	35	Cancer, protein trafficking, cell cycle
4	32	35	Gene expression, cellular growth and proliferation, hematologic system development and function
5	30	34	Cellular assembly and organization, cellular compromise, lipid metabolism
Pancreas
1	27	35	Cellular assembly and organization, cellular compromise, lipid metabolism
2	27	35	Carbohydrate metabolism, drug metabolism, small molecule biochemistry
3	27	35	Cellular assembly and organization, cancer, cell cycle
4	27	35	Cell cycle, DNA replication, recombination, and repair, cell signaling
5	27	35	RNA posttranscriptional modification, cellular assembly and organization, cellular compromise

NOTE: Genes whose translation was affected by radiation in each tumor type as defined by SAM (<1% FDR) were subjected to IPA, the top five networks with their top three associated function categories are shown. Score refers to statistical significance (negative logarithm of the P value); focus molecules refers to the number of genes (out of a possible 35) in each network.