Table 3.
Functions associated with the top 10 networks for genes whose translation state was affected by radiation in cancer and normal cell lines
| Score | Focus molecules | Top functions | |
|---|---|---|---|
| Cancer | |||
| 1 | 37 | 35 | Cancer, cell cycle, skeletal and muscular disorders |
| 2 | 35 | 34 | Connective tissue development and function, tissue development, amino acid metabolism |
| 3 | 35 | 34 | Cell cycle, cell signaling, DNA replication, recombination, and repair |
| 4 | 35 | 34 | RNA posttranscriptional modification, cell signaling, carbohydrate metabolism |
| 5 | 35 | 34 | RNA posttranscriptional modification, cell death, connective tissue development and function |
| 6 | 32 | 33 | Cellular assembly and organization, gene expression, cell cycle |
| 7 | 32 | 33 | Cancer, hematologic disease, gastrointestinal disease |
| 8 | 30 | 32 | Cell death, posttranslational modification, cancer |
| 9 | 30 | 32 | Cancer, cellular movement, protein trafficking |
| 10 | 30 | 32 | Cell signaling, DNA replication, recombination, and repair, gene expression |
| Normal | |||
| 1 | 33 | 35 | Cell-to-cell signaling and interaction, tissue development, organismal development |
| 2 | 30 | 34 | Cell cycle, cellular assembly and organization, DNA replication, recombination, and repair |
| 3 | 30 | 34 | Cellular assembly and organization, cancer, cell cycle |
| 4 | 30 | 34 | RNA posttranscriptional modification, gene expression, cellular assembly and organization |
| 5 | 30 | 34 | Amino acid metabolism, posttranslational modification, small molecule biochemistry |
| 6 | 30 | 34 | Hematologic disease, gene expression, lipid metabolism |
| 7 | 30 | 34 | Inflammatory disease, immune response, cellular development |
| 8 | 30 | 34 | Gene expression, cell signaling, lipid metabolism |
| 9 | 30 | 34 | DNA replication, recombination, and repair, cell cycle, cancer |
| 10 | 28 | 33 | Cell cycle, embryonic development, cellular assembly and organization |
NOTE: Genes whose translation was affected by radiation in normal or cancer cell lines as defined by SAM (<1% FDR) were subjected to IPA, the top 10 networks with their top 3 associated function categories are shown. Score refers to statistical significance (negative logarithm of the P value); focus molecules refers to the number of genes (out of a possible 35) in each network.