Table 4.

Univariate and multivariate Cox proportional hazards models of mortality among AIDS-defining and non-AIDS defining cancer at cancer diagnosis.

	No. of deaths	HR (95% CI)	P value	Adjusted HR (95% CI)a	P value
AIDS-defining cancer
Age group (years)
<40	53	1.0 (ref)	–	1.0 (ref)	–
40–49	24	0.94 (0.58–1.52)	0.79	1.05 (0.63–1.76)	0.84
≥50	9	1.39 (0.66–2.95)	0.38	2.21 (1.00–4.89)	0.05
Gender
Male	64	1.0 (ref)	–	1.0 (ref)	–
Female	22	1.30 (0.79–2.14)	0.30	1.96 (1.12–3.48)	0.02
Race
White	24	1.0 (ref)	–	1.0 (ref)	–
Black	62	1.35 (0.83–2.19)	0.22	1.15 (0.68–1.93)	0.60
Injection drug use	23	1.00 (0.61–1.63)	1.00
HIV-1 RNA <400 copies/mlb	17	0.48 (0.22–1.02)	0.06
CD4 cell count group(cells/μl)
>350	8	1.0 (ref)	–	1.0 (ref)	–
201–350	4	0.72 (0.22–2.40)	0.60	0.83 (0.25–2.79)	0.76
51–200	24	1.84 (0.82–4.10)	0.14	2.26 (0.98–5.23)	0.06
≤50	47	2.71 (1.27–5.75)	0.01	4.02 (1.75–9.26)	0.001
Non-AIDS-defining cancer
Age group (years)
<40	9	1.0 (ref)	–	1.0 (ref)	–
40–49	33	1.70 (0.78–3.72)	0.18	1.75 (0.77–3.99)	0.18
≥50	30	1.41 (0.64–3.10)	0.39	1.67 (0.71–3.90)	0.24
Gender
Male	54	1.0 (ref)	–	1.0 (ref)	–
Female	18	1.68 (0.96–2.95)	0.07	1.48 (0.81–2.73)	0.21
Race
White	13	1.0 (ref)	–	1.0 (ref)	–
Black	59	1.96 (1.07–3.60)	0.03	1.76 (0.95–3.29)	0.07
History of injection drug use	39	1.30 (0.81–2.09)	0.28
HIV-1 RNA <400 copies/mlb	23	0.57 (0.34–0.95)	0.03
CD4 cell count group (cells/μl)
>350	28	1.0 (ref)	–	1.0 (ref)	–
201–350	17	0.75 (0.41–1.38)	0.36	0.76 (0.41–1.39)	0.37
51–200	19	1.17 (0.64–2.14)	0.62	1.33 (0.70–2.52)	0.38
≤50	8	1.11 (0.48–2.58)	0.80	1.21 (0.50–2.90)	0.67

HR, hazards ratio; CI, confidence interval.

^aAdjusted HR from multivariate model that included age, gender, race, and CD4 cell count at the time of cancer diagnosis. Multivariate models did not include mean values of variables.

^bReference group are those with HIV-1 RNA ≥400 copies/ml at the time of cancer diagnosis.